The study of adsorption-desorption interaction of amino acids with calcium phosphates презентация

Relevance Calcium phosphates are part of bioorganic ­and pathogenic mineral formations. Interaction of organic and mineral components is important in such processes of biogenic crystallization, as the formation of bone

Слайд 1The study of adsorption-desorption interaction of amino acids with calcium phosphates
Golovchenko

K.K.
2 year , HHM-601-O
Scientific adviser:
Golovanova O.A.- Professor, Doctor of Geologo-Mineralogical Sciences Position Professor

Omsk State University. F.M. Dostoevsky
Department of Inorganic Chemistry

Omsk 2017


Слайд 2 Relevance
Calcium phosphates are part of bioorganic ­and pathogenic mineral formations.

Interaction of organic and mineral components is important in such processes of biogenic crystallization, as the formation of bone matrix mammals, as well as the emergence and growth of pathogenic entities. There are some assumptions, according to which the basis of the processes of mineralization lies in the adsorption interaction of free amino acids and associated protein molecules with inorganic components of biological liquids. In particular, such processes include adsorption-desorption interaction. The mechanism of their interaction is not fully understood.
In this regard, relevant studies aimed at studying the regularities of adsorption of amino acids on calcium phosphates.

Слайд 3The purpose of this paper is to study the specific features

of the adsorption-desorption interaction of amino acids with calcium phosphates while varying the pH of the solution.

Tasks:
The synthesis of hydroxylapatite, the study of its properties when the pH of the solution is varied;
Setting up an adsorption experiment;
The study of adsorption of amino acids on hydroxylapatite with varying parameters of the initial solution;
The study of desorption of amino acids.



Слайд 4Literature review
Adsorption
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The adsorption of preferential binding peptides to apatite-based materials. Biomaterials 30, P. 1287–1298.
Zhu X. D., Zhang H. J., Fan H. S., Li W., Zhang X. D. 2009 Effect of phase composition and microstructure of calcium phosphate ceramic particles on protein adsorption. Acta Biomater. 6, P. 1536–1541.
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Zhu X. D., Zhang H. J., Fan H. S., Li W., Zhang X. D. 2010 Effect of phase composition and microstructure of calcium phosphate ceramic particles on protein adsorption. Acta Biomater. 6, P. 1536–1541.
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Yang Y., Cui Q. A., Sahai N. 2010 How does bone sialoprotein promote the nucleation of hydroxyapatite? A molecular dynamics study using model peptides of different conformations. Langmuir 26, P. 9848–9859.

Слайд 5Pan H., Tao J., Xu X., Tang R. 2007 Adsorption processes

of Gly and Glu amino acids on hydroxyapatite surfaces at the atomic level. Langmuir 23, P. 8972–8981.
Brooks B. R., et al. 2009 CHARMM: the biomolecular simulation program. J. Comput. Chem. 30, P. 1545–1614.
Kang Y., Li X., Tu Y., Wang Q., Agren H. 2010 On the Mechanism of Protein Adsorption onto Hydroxylated and Nonhydroxylated TiO2 Surfaces. J. Phys. Chem. C. 114, P. 14 496–14 502.
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Слайд 6de Leeuw N. H., Rabone J. A. L. 2007 Molecular dynamics

simulations of the interaction of citric acid with the hydroxyapatite (0001) and (011−0) surfaces in an aqueous environment Cryst. Eng. Commun. 9. P. 1178-1186
Rimola A., Corno M., Zicovich-Wilson C., Ugliengo P. 2008 Ab-initio modelling of protein/biomaterial interactions: glycine adsorption at hydroxyapatite surfaces J. Am. Chem. Soc 130. P. 16181-16183.
Rimola A., Corno M., Zicovich-Wilson C. M., Ugliengo P. 2009 Ab initio modeling of protein/biomaterial interactions: competitive adsorption between glycine and water onto hydroxyapatite surfaces Phys. Chem. Chem. Phys 11. P. 9005-9007.
Almora-Barrios N., Austen K. F., de Leeuw N. H. 2009 Density functional theory study of the binding of glycine, proline, and hydroxyproline to the hydroxyapatite (0001) and (010) surfaces Langmuir 25. P. 5018-5025.

Слайд 7Crystal chemistry of calcium phosphates
Silva G. A., Coutinho O. P., Ducheyne

P., Reis R. L. 2007 Materials in particulate form for tissue engineering. II. Applications in bone. J. Regen. Med. V. 1. P. 97–106.

Desorption of amino acids
Xiuli Dong, Qi Wang, Tao Wu, and Haihua Pan. Understanding Adsorption-Desorption Dynamics of BMP-2 on Hydroxyapatite (001) Surface. Department of Chemistry, Zhejiang University, Hangzhou, China. Biophysical Journal. V. 93 August 2007. Р. 750–759.
Chen, X., Q. Wang, J. Shen, H. Pan, and T. Wu. 2007. Adsorption of LRAP on hydroxyapatite (001) surface through –COO claws. J. Phys. Chem. C. 111. Р. 1284–1290.
Huimin Huimin Wang Huimin Wang ;  Guihua Nie Huimin Wang ;  Guihua Nie ;  Kui Fu. Cellular Automata Model of Protein Adsorption on the Surface of Bioceramics. 2008. P. 417-420. (DOI: 10.1109/ICNC.2008.611)
Chie KojimaChie Kojima,Kenji WatanabeChie Kojima,Kenji Watanabe. Adsorption and Desorption of Bioactive Proteins on Hydroxyapatite for Protein Delivery Systems. J Drug Deliv. 2012. P. 932461. (doi:  10.1155/2012/932461)


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