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Preventing the preventable cancer презентация
Содержание
- 1. Preventing the preventable cancer
- 2. Fact is ……. While it is possible for a
- 3. Global Burden of Cervical Cancer
- 4. Courtesy Dr Jalaa Taher, HAAD
- 5. Cytology based screening for Cervical Cancer
- 6. Limitations of cytology
- 7. Reproducibility of Cervical cytology after reviewing 5000 slides
- 9. Cytology Screen categories Bethesda Scoring
- 10. Management of women with LSIL
- 11. Draw backs of cytology screening (Roche submission to US FDA March 2014)
- 12. Harald zur Hausen 1984 isolated HPV 16 from Cx tissue Awarded Nobel Prize 2008
- 14. Relative sensitivities of cytology & HPV testing
- 17. Co Testing
- 18. Genotypes separately & simultaneously reported by Star Metropolis Clinical Lab
- 19. Primary HR HPV Screening with reflux cytology
- 20. Courtesy Dr Jalaa Taher, HAAD
- 21. Courtesy Dr Jalaa Taher, HAAD
- 22. Courtesy Dr Jalaa Taher, HAAD
- 23. UAE study Age distribution n = 314
- 24. HPV Genotypes in UAE n = 126 8 LR genotypes 14 HR genotypes
- 25. Genotype distribution in different age groups (n = 126)
- 26. HPV genotypes in UAE 14 HR genotypes
- 27. HPV Genome E1-E7 = “Early” genes (nonstructural)
- 28. Why Cervical Cancer is preventable ? Natural History of HPV infection
- 30. HPV-containing double stranded DNA ‘Empty’ non-infectious virus-like
- 31. Vaccines Gardasil (2006) : Contains HPV
- 33. Two Opportunities to prevent Cx Ca Normal
- 35. Collection of Cx Swab
- 50. Cervical Cancer is entirely preventable Vaccination
- 51. Please Join, Support & Promote Scientists have
Fact is ……. While it is possible for a
Слайд 27HPV Genome
E1-E7 = “Early” genes (nonstructural)
L1, L2 = Capsid genes
URR =
upstream regulatory region
E6 & E7 proteins play major role in immortality & malignant transformation of infected cells
E5 has role, but not required to maintain cancer phenotype
E6 & E7 proteins play major role in immortality & malignant transformation of infected cells
E5 has role, but not required to maintain cancer phenotype
Munoz et al. 2006.
Слайд 30HPV-containing double stranded DNA
‘Empty’ non-infectious virus-like particle (VLP) mimics the virus
Virus-like
particles (VLPs) as HPV vaccine antigens mimic the virus structure
Stanley M, et al. Vaccine 2006; 24(suppl 3):S3/106–113.
Слайд 31Vaccines
Gardasil (2006) :
Contains HPV 16, 18, 6, 11
Cerverix (2009): Contains
HPV 16, 18
Females 10 through 25
For:
Ca Cx
CIN
Adenocarcinoma in situ
Gardasil for males too and for Ca Anus, warts etc
Females 10 through 25
For:
Ca Cx
CIN
Adenocarcinoma in situ
Gardasil for males too and for Ca Anus, warts etc
Слайд 33Two Opportunities to prevent Cx Ca
Normal cervix
HPV infection
Cervical Intraepitheilial neoplasia
CIN
Cervical
Cancer
HPV vaccine
HPV & Cx screen & t/t
- 18 18 – 25 > 30
Слайд 50Cervical Cancer is entirely preventable
Vaccination before exposure
Screening after 30 yrs (every
5 yrs)
Though STI,
it does not imply un-faithfullness
Cancer free RAK / UAE by 2020
Become a national achievable goal
Insurance be instructed to approve
Vaccination & Co-testing
Though STI,
it does not imply un-faithfullness
Cancer free RAK / UAE by 2020
Become a national achievable goal
Insurance be instructed to approve
Vaccination & Co-testing
Слайд 51Please Join, Support & Promote
Scientists have the tools, but cannot do
it alone
Thank you for your attention
