Trypanosomiasis презентация

Содержание

1. Trypanosomiasis
2. History its species was discovered by a
3. Introduction The name is derived from Greek
4. Trypanosoma
5. Morphology of trypanosome
6. African Trypanosomiasis (Sleeping Sickness)
7. The parasites Belong to a group
8. T. rhodesiense causes E. African trypanosomiasis T. gambiense causes W. and Central African sleeping sickness Distribution
9. Trypanosoma brucei species
11. Transmission A bite from an infected tsetse
12. Life cycle
13. Pathogenesis
14. Clinical presentation Incubation period may be from
16. Clinical presentation
17. Diagnosis
18. Diagnosis General Anemia, hypergammaglobulinemia, low complement levels,
19. Imaging Studies CT scanning and MRI of
20. Treatment
21. American Trypanosomiasis ( Chagas Disease)
22. Distribution
23. Morphology
24. Transmission
25. Life cycle
26. Transmission
27. Pathogenesis
28. Pathogenesis
29. Diagnosis
30. Diagnosis (Xenodiagnosis)
31. Diagnosis
32. Chronic stage. In chronic stage these
33. Gigantism of midgut Clinical presentation
34. Treatment
35. Control

History its species was discovered by a scientist Valentine” in 1841. But these are found in mammals after 50 – 80 years later. Then further studied about their diseases.

Слайд 1Trypanosomiasis
The topic of the lecture:
Professor Kutmanova A.Z.

Слайд 2History
its species was discovered by a scientist Valentine” in 1841.
But

these are found in mammals after 50 – 80 years later.
Then further studied about their diseases.

Слайд 3Introduction
The name is derived from Greek word,
trypano means (borer)
soma

means (body)
They are unicellular flagellate protozoa.
Have spiral like motion.
Need more than one host to complete its life cycle.
Oftenly transmitted by a vector.
Generally found in intestine, but some time found in blood stream or in heart.

Слайд 4Trypanosoma

Слайд 5Morphology of trypanosome

Слайд 6African Trypanosomiasis (Sleeping Sickness)

Слайд 7The parasites
Belong to a group of closely related trypanosomes in

the Trypanosoma brucei species complex. Three morphologically indistinguishable species are recognized:
T. brucei infects game animals/livestock (causes nagana)
T. rhodesiense causes E. African trypanosomiasis
T. gambiense causes W. and Central African sleeping sickness
(Some authors consider these as subspecies: T. brucei brucei, T. b. rhodesiense, T. b. gambiense.)

Слайд 8T. rhodesiense causes E. African trypanosomiasis
T. gambiense causes W. and Central African sleeping

sickness

Distribution

Слайд 9Trypanosoma brucei species

Слайд 10

Слайд 11Transmission
A bite from an infected tsetse fly causes African trypanosomiasis.
Blood transfusions

are a rare cause of parasitic transmission.
In rare cases, accidental transmission in the laboratory has been implicated.

Слайд 12Life cycle

Слайд 13Pathogenesis

Слайд 14Clinical presentation
Incubation period may be from few days to weeks.
The

first clinical manifestation of African trypanosomiasis chancre occurs at the site of inoculation .

Слайд 15

Слайд 16Clinical presentation

Слайд 17Diagnosis

Слайд 18Diagnosis
General
Anemia, hypergammaglobulinemia, low complement levels, elevated ESR, thrombocytopenia, hypoalbuminemia, but not

eosinophilia or abnormal liver function.
The total IgM level is higher in blood and CSF.
A definitive diagnosis of infection requires actual detection of trypanosomes in blood, lymph nodes, CSF, skin chancre aspirates, or bone marrow.
However, symptomatic improvement after empiric treatment is the usual confirmatory test in areas where diagnostic studies are not readily available.

Слайд 19Imaging Studies
CT scanning and MRI of the head: Both head CT

scanning and MRI reveal cerebral edema and white matter enhancement, respectively, in patients with late-stage African trypanosomiasis.
EEG in neurologic involvement usually shows slow wave oscillations (delta waves), a nonspecific finding