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Megaloblastic anemia презентация
Содержание
- 1. Megaloblastic anemia
- 2. Objectives Body stores and daily requirements
- 3. Requirements for Red Blood Cell Production
- 4. Vitamin B 12 and Folate
- 7. Macrocytic anemia with hypersegmented neutrophil
- 8. Macro-ovalocyte in megaloblastic anemia
- 9. Macro-ovalocyte in megaloblastic anemia
- 10. Megaloblastic Anemia – Bone Marrow
- 11. Bone marrow - megaloblasts
- 15. Important for DNA synthesis, nervous tissue and
- 21. Absorption and transport of vitamin B12
- 22. Absorption and transport of vitamin B12
- 24. B12 /
- 27. Pernicious Anemia (PA) Early graying of hair Blue eyes
- 28. Pernicious Anemia Red beefy tongue
- 29. Pernicious Anemia Vitiligo
- 30. Normal Gastric atrophy PA
- 31. Atrophic Gastritis
- 35. Hematologic Megaloblastic anemia Pancytopenia (leukopenia, thrombocytopenia) Neurologic
- 38. The patient was a 45 year old
- 39. Subacute Combined Degeneration of Spinal Cord
- 56. Reticcount
- 58. Thank You
Objectives Body stores and daily requirements of vitamin B12 and folate Absorption of vitamin B12 and folate from the gut Causes of vitamin B12 and folate deficiency Hematological consequences of
Слайд 2Objectives
Body stores and daily requirements of vitamin B12 and folate
Absorption
of vitamin B12 and folate from the gut
Causes of vitamin B12 and folate deficiency
Hematological consequences of vitamin B12 and folate deficiency
Neurological sequelae of vitamin B12 deficiency
Diagnosis and management of megaloblastic anemia
Diagnosis and management of Pernicious Anemia
Causes of vitamin B12 and folate deficiency
Hematological consequences of vitamin B12 and folate deficiency
Neurological sequelae of vitamin B12 deficiency
Diagnosis and management of megaloblastic anemia
Diagnosis and management of Pernicious Anemia
Слайд 3Requirements for Red Blood Cell Production
Proteins, required for globin synthesis
Iron
Erythropoeitin
Vitamin B12 and folic acid
Vitamin B6
Vitamin C
Thyroid hormones, estrogens and androgens
Слайд 15Important for DNA synthesis, nervous tissue and fat metabolism in the
liver
an intermediate of the citric acid cycle, porphyrin synthesis
(Heme synthesis)
Слайд 35Hematologic
Megaloblastic anemia
Pancytopenia (leukopenia, thrombocytopenia)
Neurologic
Paresthesias
Peripheral neuropathy
Combined systems disease (demyelination of dorsal columns
and corticospinal tract)
Psychiatric
Irritability, personality change
Mild memory impairment, dementia
Depression
Psychosis
Cardiovascular
Possible increased risk of myocardial infarction and stroke
Psychiatric
Irritability, personality change
Mild memory impairment, dementia
Depression
Psychosis
Cardiovascular
Possible increased risk of myocardial infarction and stroke
Clinical Manifestations of Vitamin B12 Deficiency
Слайд 38The patient was a 45 year old woman. She had a
swollen tender tongue, parasthesias of both feet and hands, decreased proprioception and vibratory sensation, ataxia and leg weakness.
