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DIC - disseminated intravascular coagulation.TTP - thrombotic thrombocytopenic purpura презентация
Содержание
- 1. DIC - disseminated intravascular coagulation.TTP - thrombotic thrombocytopenic purpura
- 2. DIC-Disseminated intravascular coagulation
- 3. Widespread coagulation activation Unregulated consumption of thrombocytes ad coagulation factors Bleeding or thrombosis
- 5. Bleeding is most frequent Bleeding of
- 6. DIC - Reasons Sepsis Gynecological catastrophe –
- 8. Chronic DIC Slow, sub-clinical course Malignancy- prostata, pancrease Intrauterine death Aortic aneurism Large hemangioma
- 9. DIC- laboratory tests Prolonged PT, PTT Low fibrinogen Low thrombocytes High D-Dimers
- 11. DIC - Treatment Treatment of the precipitating
- 12. TTP- Thrombotic Thrombocytopenic Purpura von Willebrand factor
- 14. TTP Clinical Syndrome Thrombocytopenia Hemolytic anemia High LDH Neurological symptoms RBC fragments
- 15. Inherited lack of ADAMTS13 Acquired antibodies
- 16. TTP- treatment Plasmapheresis with plasma or albumin Rithuximab Avoid thrombocytes infusion
DIC-Disseminated intravascular coagulation
Слайд 1DIC- disseminated intravascular coagulation
TTP- Thrombotic Thrombocytopenic Purpura
Dr Tzoran Inna
Thrombosis and Hemostasis
Слайд 3
Widespread coagulation activation
Unregulated consumption of thrombocytes ad coagulation factors
Bleeding or thrombosis
Слайд 5
Bleeding is most frequent
Bleeding of skin and gastrointestinal tract
Thrombosis frequently associated
with malignancy
Слайд 6DIC - Reasons
Sepsis
Gynecological catastrophe – abruptio placenta, amniotic fluid emboli
Malignancy-APL
Multiple trauma
Burns
Hypertermia
Snake
bite
Слайд 8Chronic DIC
Slow, sub-clinical course
Malignancy- prostata, pancrease
Intrauterine death
Aortic aneurism
Large hemangioma
Слайд 11DIC - Treatment
Treatment of the precipitating factor
Bleeding treated with FFP, thrombocytes,
cryoprecipitate
Thrombosis treated with heparin, LMWH
Newest treatments
Activated Protein C
TFPI
Anti-thrombin
Thrombosis treated with heparin, LMWH
Newest treatments
Activated Protein C
TFPI
Anti-thrombin
Слайд 12TTP- Thrombotic Thrombocytopenic Purpura
von Willebrand factor (vWF) cleaving protease
ADAMTS 13
deficiency
Accumulation of large multimers of VWF
Accumulation of large multimers of VWF
Слайд 14TTP
Clinical Syndrome
Thrombocytopenia
Hemolytic anemia
High LDH
Neurological symptoms
RBC fragments
Слайд 15
Inherited lack of ADAMTS13
Acquired antibodies to ADAMTS 13
Gram neg bacteremia
Pregnancy
Drugs
HIV
Malignancy
Organ or
BM transplantation
