Слайд 1Why Juno Therapeutics Jumped 12% In September
                                                            
                                                                    
                            							
														
						 
											
                            Слайд 2What:
This clinical-stage biotech company is researching T-cell cancer therapies.
JCAR 015 for
                                                            
                                    lymphoma & leukemia.
Various others in early stage trials for leukemia & lymphoma.
Shares jumped 12.1% in September.
Presented at Morgan Stanley’s Global Healthcare Conference on September 16.
                                
                            							
							
							
						 
											
											
                            Слайд 4So What:
Reengineering immune system’s T-cells.
Using chimeric antigen receptor (CAR) approach to
                                                            
                                    allow T-cells to bind to and kill cancer cells.
Potential FDA filing in late 2016/early 2017.
10 drug candidates in human trials by 1H2016.
Collaborating with Celgene.
                                
                            							
														
						 
											
											
                            Слайд 6So what continued…
JCAR 015:
87% complete response/remission rate in relapsing/recurring adult acute
                                                            
                                    lymphoblastic leukemia.
JCAR 017:
91% complete response/remission rate in relapsing/recurring pediatric acute lymphoblastic leukemia.
                                
                            							
														
						 
											
                            Слайд 7Now what:
JCAR 015:
Phase 2 pivotal trial ongoing.
Began in Q3 2015.
Scheduled to
                                                            
                                    complete in 2017.
                                
                            							
														
						 
											
                            Слайд 8Now what continued:
Needs to confirm prior findings.
Watch safety data.
Focus on rates
                                                            
                                    of cytokine response syndrome.
23% rate in prior studies.
Remember, this is a clinical stage company without revenue and without products on the market.
Suitable only for the most risk tolerant of investors.
                                
                            							
														
						 
											
                            Слайд 9
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