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What’s New???Reproductive Medicine презентация
Содержание
- 1. What’s New???Reproductive Medicine
- 2. Why!!! To be updated To modify To share
- 3. Progesterone
- 4. Brain Progesterone can be produced in
- 5. Progesterone for acute brain trauma
- 6. Progesterone & Preterm labor Mainly for prevention
- 7. Idea Progesterone after preterm labor For the preterm baby
- 8. Why To protect the fetal brain To improve brain development
- 9. Preterm fetus: Deprived from P4
- 10. Trottet et al, 2012 First case preterm
- 11. Genomic Sequencing The coming Era
- 12. DNA sequencing Rapidly evolving Allow genetic diagnosis
- 13. Work flow of conventional versus second-generation sequencing
- 14. 1. Prepare genomic DNA 2. Attach DNA
- 15. 7. Determine first base 8. Image first
- 16. Preimplantation Genetic Diagnosis (PGD)
- 17. Which Embryo is Disease-Free?
- 18. Non Invasive Prenatal Diagnosis Minimise the need
- 19. Towards Better Gene Therapy
- 20. Spindle transfer !!!!! spindle-chromosomal complex transfer
- 21. Back to Simple Ideas
- 22. High dose FSH at hCG triggering Novel
- 23. LH surge is associated with FSH surge to a lesser extent
- 24. Outcome?? 10% increase in PR??
- 25. Corifolitropin alfa Long acting FSH Under the
- 26. Increasing LBR with Diagnostic Hysteroscopy
- 27. Dienogest 19-nortestosterone derivative Endometriosis Menorrhagia COC Pituitary suppression
- 28. DNG in endometriosis no glucocorticoid
- 29. COC This maintenance beneficial E2 effects is
- 30. Ulipristal acetate & Fibroids oral selective progesterone
- 31. Thank you Professional Diploma
Why!!! To be updated To modify To share
Слайд 4Brain
Progesterone can be produced in the brain from steroid precursors.
they have
been found to have neuroprotective function.
Слайд 6Progesterone & Preterm labor
Mainly for prevention of preterm labor
But still there
are many preterm labor
Liable to cerebral palsy and delayed neural development
Liable to cerebral palsy and delayed neural development
Слайд 12DNA sequencing
Rapidly evolving
Allow genetic diagnosis of diseases
Allow prediction for disease later
in life
Determine human genome in details
Now Next generation Sequencer
Determine human genome in details
Now Next generation Sequencer
Слайд 141. Prepare genomic DNA 2. Attach DNA to surface 3. Bridge
amplification
4. Fragement become double stranded
5. Denature the double stranded molecules
6. Complete amplification
4. Fragement become double stranded
5. Denature the double stranded molecules
6. Complete amplification
Illumina
ABI SOLiD
Roche 454
HeliScope
What is next-generation sequencing ?
Слайд 157. Determine first base
8. Image first base
9. Determine second base
10. Image
second base
11. Sequence reads over multiple cycles
12. Align data.
1 billion bases per run, 1% of the cost of capillary-based method.
11. Sequence reads over multiple cycles
12. Align data.
1 billion bases per run, 1% of the cost of capillary-based method.
Слайд 18Non Invasive Prenatal Diagnosis
Minimise the need for amniocenecis
Cell free DNA (fetal
in maternal blood)
High accuracy
High accuracy
Слайд 20Spindle transfer !!!!!
spindle-chromosomal complex transfer
taking nuclear DNA from an egg cell
and transferring that DNA into another egg cell, leaving the defective mitochondrial DNA behind
For genetic disease
Safety?????? Gene therapy
For genetic disease
Safety?????? Gene therapy
Слайд 22High dose FSH at hCG triggering
Novel concept
Give four ampoules of FSH
at time of hCG injection
Why??????
Why??????
Слайд 25Corifolitropin alfa
Long acting FSH
Under the name of Elonva
Single shot
Contraindicated with PCOS
Not
self administered
Not cheaper
Not cheaper
Слайд 28DNG in endometriosis
no glucocorticoid
no antimineralocorticoid activity.
no antiestrogenic activity
due
to DNG's low gonadotropic activity, E2 levels are not decreased to zero, in contrast to treatments with gonadotropin-releasing hormone (GnRH) analogues.
Слайд 29COC
This maintenance beneficial E2 effects is of particular importance for the
general tolerability of the first contraceptive pill to use E2V instead of EE
safer??
safer??
Слайд 30Ulipristal acetate & Fibroids
oral selective progesterone receptor modulator (SPRM) that has
successfully completed phase III clinical trials.
licensed in Western Europe
has shown efficacy with a significant reduction in uterine bleeding, fibroid volume, and improved quality of life
low side effects unlike (GnRH) agonists.
licensed in Western Europe
has shown efficacy with a significant reduction in uterine bleeding, fibroid volume, and improved quality of life
low side effects unlike (GnRH) agonists.
