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Lipid metabolism. Part 2 презентация
Содержание
- 1. Lipid metabolism. Part 2
- 2. Phospholipid
- 3. Self-organization of phospholipids
- 4. Cleavage sites of phospholipases
- 5. Phosphatidyl inositol calcium system PiP2
- 6. Phospholipase A2 of bee venom
- 7. The synthesis of acetylcholine choline acetylcholine Choline acetyl-transferase
- 8. Phospholipid synthesis
- 9. Violations of complex lipid metabolism 4 3
- 10. Polyunsaturated fatty acids Linoleic acid (18:2;9,12) Linolenic acid (18:3;9,12,15) Arachidonic acid (20:4;5;8,11,14)
- 11. Eicosanoids synthesis
- 13. Cholesterol
- 14. Cholesterol ester
- 15. Classification of steroids С 27 (8)
- 16. Cholesterol synthesis Acetyl-CoA acetyltransferase Acetoacetyl-CoA 2
- 19. mevalonate farnesyl pyrophosphate (С15) ATP farnesyl pyrophosphate (С15) NADPH+H+ squalene (C30)
- 21. Regulation of cholesterol synthesis
- 22. Regulation of cholesterol synthesis
- 23. Cholesterol ester metabolism Acylcholesterol + Н2О→ Fatty acid + Cholesterol
- 26. Cholesterol 3-α,7-α- diol 3-α,7-α- diol 7-α-hydroxy cholesterol Chenodeoxycholic
- 27. Bile acid synthesis
- 28. Stationary state (Cholesterol endog + Cholesterol exog)
- 29. Joseph L. Goldstein
- 30. Hyperlipidemia classification * * * *
- 32. Cholesterol metabolism
- 33. Atherosclerosis
- 35. Atherosclerotic plaque
- 36. Atherosclerotic plaque is surgically scraped from artery
- 37. Cholelithiasis
- 38. Xanthomatosis
Phospholipid
Слайд 9Violations of complex lipid metabolism
4
3
2
1
1 - Gaucher disease (glucocerebrosidase deficiency)
2
- Krabbe disease (galactocerebrosidase deficiency)
3 - Farber disease (ceramidase deficiency)
4 - Niemann-Pick disease (sphingomielinidase deficiency)
3 - Farber disease (ceramidase deficiency)
4 - Niemann-Pick disease (sphingomielinidase deficiency)
Слайд 10Polyunsaturated fatty acids
Linoleic acid (18:2;9,12)
Linolenic acid (18:3;9,12,15)
Arachidonic acid (20:4;5;8,11,14)
Слайд 19mevalonate
farnesyl pyrophosphate (С15)
ATP
farnesyl pyrophosphate (С15)
NADPH+H+
squalene (C30)
Слайд 26Cholesterol
3-α,7-α- diol
3-α,7-α- diol
7-α-hydroxy cholesterol
Chenodeoxycholic acid
Cholic acid
7-α-hydroxylase
Reduction, hydroxylation
Side chain oxydation
Side chain oxydation
Bile acid
synthesis
Слайд 28Stationary state
(Cholesterol endog + Cholesterol exog) =
= (Cholesterol excr +
Bile acids excr)
