Muscular tissue презентация

CONTRACTILE STRUCTURES (CELLS AND FIBERS) MUSCULAR TISSUE NONMUSCULAR MYOFIBROBLASTS MYOEPITHELIAL CELLS PERICYTES

Слайд 1MUSCULAR
TISSUE


Слайд 2CONTRACTILE STRUCTURES
(CELLS AND FIBERS)
MUSCULAR
TISSUE
NONMUSCULAR
MYOFIBROBLASTS
MYOEPITHELIAL CELLS
PERICYTES


Слайд 3MUSCULAR TISSUE
STRIATED
SMOOTH
SKELETAL
CARDIAC
(HEART MUSCLE,
MYOCARDIUM)


Слайд 4DEVELOPMENT
OF MUSCULAR TISSUE
MYOTOMES –
SKELETAL TISSUE
SPLANCHNOTOME –
CARDIAC TISSUE
NEUROECTODERM –
MYONEURAL TISSUE
OF THE

EYE

MESENCHYME – SMOOTH MUSCLE TISSUE


Слайд 5SPECIALIZED COMPARTMENTS
OF MUSCULAR STRUCTURES
CONTRACTILE
APPARATUS
SUPPORTING
APPARATUS
Ca++ - STORING
MEMBRANE SYSTEM
MYOFIBRILS IN


STRIATED MUSCLES;

DISPERSED
MYOFILAMENTS IN
SMOOTH MUSCLE
CELLS.

LINKING PROTEINS
OF CYTOPLASM;

EXTERNAL LAMINA
(BASAL MEMBRANE);

EXTERNAL CONNECTIVE TISSUE (FASCIA OF SKELETAL MUSCLES ….)

SARCOTUBULAR SYSTEM
IN STRIATED MUSCLES;

CYSTERNAE OF sER AND
CAVEOLI IN SMOOTH
MUSCLE CELLS


Слайд 6SKELETAL MUSCLE TISSUE
SKELETAL MUSCLE FIBER
MYOSYMPLAST
MULTINUCLEATE STRUCTURE
FORMED BY FUSION OF MANY
HUNDREDS OF

MYOBLASTS IN
DEVELOPMENT

SATELLITE CELLS

PRECURSOR CELLS ABLE TO
DEVIDE BY MITOSIS TO FORM
NEW MUSCLE AFTER TISSUE
DAMAGE

SURROUNDED BY AN EXTERNAL
LAMINA TOGETHER


Слайд 7SECTION OF SKELETAL MUSCLE -
CROSS AND LONGITUDINAL


Слайд 8SUPPORTING CONNECTIVE TISSUE
OF SKELETAL MUSCLE


Слайд 9CARDIAC MUSCLE TISSUE
CARDIAC MUSCLE CELLS
LINKED END BY END INTO SO NAMED

FIBERS

BY INTERCALATED DISKS

Слайд 10CARDIAC MUSCLE TISSUE


Слайд 11STRUCTURE OF MYOFIBRILS
LIGHT MICROSCOPY -
HIGH MAGNIFICATION
SCHEME OF INTERNAL
STRUCTURE


Слайд 12STRUCTURE OF THIN FILAMENTS


Слайд 13STRUCTURE OF THICK FILAMENTS


Слайд 14LINKING (ACCESSORY) PROTEINS
OF MUSCLE TISSUE
ACTININ – HOLDS THIN FILAMENTS IN

THE Z-DISK (LINE)

MYOMESIN – HOLDS MYOSIN FILAMENTS IN THE REGION OF M-LINE

TITIN (CONNECTIN) – LINKS THE ENDS OF THICK FILAMENTS TO
THE Z-LINE

DESMIN – LINK ADJACENT MYOFIBRILS TO EACH OTHER

C-PROTEIN – MYOSIN BINDING PROTEIN

DYSTROPHIN – PLASMA MEMBRANE PROTEIN, BRIDGES ACTIN
FILAMENTS TO THE EXTERNAL LAMINA TO TRANSFER THE INTERNAL
FORCES OF CONTRACTION TO THE EXTERNAL TISSUES


Слайд 15MYOFIBRILS – SARCOTUBULAR SYSTEM
RELATIONS


Слайд 16TRIADS OF SARCOTUBULAR SYSTEM


Слайд 17THE MOLECULAR BASIS
OF STRIATED MUSCLES CONTRACTION
DEPOLARIZATION OF PLASMA
MEMBRANE AND

SARCOTUBULAR
SYSTEM

RELEASE OF Ca++ INTO THE
CYTOPLASM VIA MEMBRANE CHANNELS

BINDING OF Ca-IONS TO THE TROPONIN
(TROPONIN C) RESULTING IN CHANGES OF
TROPONIN COMPLEX

ACCESS OF MYOSIN TO
THE ACTIN FILAMENTS

HYDROLYSIS OF ATP

CONTRACTION


Слайд 18INTERCALATED DISKS OF CARDIAC MUSCLE CELLS
PLASMA MEMBRANES
OF CARDIAC CELLS,

DESMOSOMES,

GAP JUNCTIONS,

ADHERENT-TYPE
JUNCTIONS (FASCIAE
ANHERENS)
STRUCTURES


Слайд 19HISTOLOGY OF SMOOTH MUSCLES


Слайд 20Ca++- ENTRY INTO CYTOPLASM
OF SMOOTH MUSCLE CELL
FROM SMOOTH ENDOPLASMIC RETICULUM


(VESICLES LIKE SARCOTUBULAR SYSTEM OF STRIATED MUSCLES)

FROM EXTRACELLULAR SPACES

VIA HORMONES-DEPENDENT
(LIGAND-GATED) CHANNENL

VIA DEPOLARIZATION-DEPENDENT
(VOLTAGE-GATED) CHANNELS


Слайд 21THE MOLECULAR BASIS
OF SMOOTH MUSCLES CONTRACTION
MEMBRANE EXCITATION
Ca++ RELEASE INTO CYTOPLASM
BINDING

TO THE PROTEIN –
CALMODULIN

ACTIVATION OF ENZIME –
MYOSIN LIGHT-CHANE KINASE

PHOSPHORYLATION
OF MYOSIN

ACCESS OF MYOSIN TO
THE ACTIN FILAMENTS

CONTRACTION


Слайд 22RELAXED AND CONTRACTED SMOOTH MUSCLE CELLS


Слайд 23REGENERATION
OF MUSCLE TISSUES
SKELETAL
MITOTIC DIVISION OF SATELLITE CELLS
HYPERTROPHY OF REMAINING FIBERS
(A

RESULT OF MULTIPLICATION OF ORGANELLES –
MYOFIBRILS AND MITOCHONDRIA MAINLY)

SMOOTH

MITOTIC DIVISION OF CELLS

HYPERTROPHY OF REMAINING CELLS

CARDIAC

HYPERTROPHY OF REMAINING
CELLS ONLY - UNFORTUNATELLY


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