Enterobacteriaceae (Gram negative rods enteric tract) презентация

Содержание

Key Words Opportunistic diseases Shigella Diarrhea - Bacillary dysentery Dysentery - Shiga toxin Urinary tract infections Salmonella enteritidis Pili Salmonellosis Lactose

Слайд 1 Enterobacteriaceae
(Gram negative rods enteric tract)

Слайд 2Key Words
Opportunistic diseases Shigella
Diarrhea - Bacillary dysentery
Dysentery

- Shiga toxin
Urinary tract infections Salmonella enteritidis
Pili Salmonellosis
Lactose positive/negative Salmonella cholerae-suis
Enterohemorrhagic E. coli Salmonella typhi
- Vero toxin (Shiga-like) - Typhoid
- Hemolysin - Vi
Enterotoxigenic E. coli Yersinia entercolitica
- Heat stable toxin Vibrio cholerae
- Heat labile toxin Choleragen (cholera toxin)
Enteropathogenic E. coli Campylobacter jejuni
Enteroaggregative E. coli Helicobacter pylori
Enteroinvasive E. coli


Слайд 3septicemia,
pneumonia,
meningitis
urinary tract infections


Citrobacter Enterobacter
Escherichia
Hafnia
Morganella
Providencia
Serratia

Opportunistic diseases
-Enterobacteriaceae

Слайд 4Enterobacteriaceae
gastrointestinal diseases
Escherichia coli
Salmonella
Shigella
Yersinia entercolitica


Слайд 5
Histocompatibility antigen (HLA) B27


Enterobacteriaceae
Salmonella
Shigella
Yersinia
Non-Enterobacteriaceae
Campylobacter
Chlamydia

Reiter's syndrome

Слайд 6 community acquired
otherwise healthy people
Klebsiella pneumoniae
respiratory

diseases
prominent capsule

urinary tract infection
fecal contamination
E. coli
Proteus
urease (degrades urea)
alkaline urine



Enterobacteriaceae

Слайд 7E. coli fimbriae



mannose
Type 1

galactose
glycolipids
glycoproteins
P














Слайд 8Enterobacteriaceae
gram negative facultative anaerobic rods
– oxidase negative (no cytochrome oxidase)

Слайд 9 E. coli
lactose positive
not usually identified
lactose

positive sp. common, healthy intestine
Shigella, Salmonella,Yersinia
lactose negative
identified



Feces

Слайд 10 other sites
identified biochemically


Enterobacteriaceae

Слайд 11Serotypes
reference laboratory
antigens
O (lipopolysaccharide)
H (flagellar)
K (capsular)


Слайд 12Diarrhea (watery feces) and Dysentery (blood in stools)

Слайд 13 Caption: E. coli
Escherichia coli

Слайд 14
E. coli and Shigella
genetically very similar
separated for historical reasons
overlap in

pathogenesis

Escherichia coli

Слайд 15Enterohemorrhagic E. coli
Usually O157:H7

Flagella

Слайд 16Transmission – meat products or sewage-contaminated vegetables
Hemorrhagic
Bloody dysentery
copious

diarrhea
few leukocytes
afebrile
hemolytic-uremic syndrome
hemolytic anemia
thrombocytopenia (low platelets)
kidney failure

Слайд 17 Vero toxin
“shiga-like toxin”


Hemolysins
Enterohemorrhagic E. coli

Слайд 18Enterotoxigenic E. coli

diarrhea like cholera
milder
travellers

diarrhea

Слайд 19Enterotoxigenic E. coli

Heat labile toxin
like choleragen
Adenyl cyclase activated
cyclic AMP


secretion water/ions

Heat stable toxin
Guanylate cyclase activated
cyclic GMP
uptake water/ions





Слайд 20Enteropathogenic E. coli

destruction of surface microvilli
fever
diarrhea

vomiting
nausea
non-bloody stools (not generally seen as dysentery)


Gut lumen

Слайд 21Enteroaggregative
Brick-like bacterial aggregates - cell surfaces

Mucus biofilm inhibits fluid

absorption

Diarrhea

Слайд 22 Dysentery
- resembles shigellosis


Enteroinvasive E. coli (EIEC )

Gut lumen

Слайд 23Treatment -gastrointestinal disease
fluid replacement
antibiotics
not used usually unless systemic
e.g. hemolytic-uremia

syndrome

Слайд 24Shigella
Modified from Fig, Dennis Kunkel

Слайд 25Shigella
S. flexneri, S. boydii, S. sonnei, S. dysenteriae
bacillary dysentery
shigellosis
bloody feces
intestinal

pain
pus

Слайд 26Shigellosis
within 2-3 days
epithelial cell damage


Gut lumen

Слайд 27Shiga toxin
enterotoxic
cytotoxic
inhibits protein synthesis
lysing 28S rRNA

Слайд 28Shigellosis
man only "reservoir"
mostly young children
fecal to oral contact
children to adults
transmitted

by adult food handlers
unwashed hands


Слайд 29Treating shigellosis
manage dehydration
patients respond to antibiotics
disease duration diminished

Слайд 30

Salmonella

Слайд 31Salmonella
2000 antigenic "types”
genetically single species
S. enterica
disease category
S. enteritidis
many serotypes
S.

cholerae-suis
S. typhi


Слайд 32Salmonellosis
S. enteritidis
the common salmonella infection
poultry, eggs
no human reservoir
Gastroenteritis
nausea
vomiting
non-bloody

stool
self-limiting (2 - 5 days)

Слайд 33Control of salmonellosis
Monitoring of food in the US is limited
microbiology is

difficult
Regulation is not optimal
Chickens are not vaccinated in US
UK, salmonellosis largely erradicated

Слайд 34Salmonellosis



uncomplicated cases (the vast majority)
antibiotic therapy not useful
Gut lumen

Слайд 35S. cholerae-suis
much less common
septicemia
antibiotic therapy essential

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