Слайд 1Lecture 3
Tissues.
1. Epithelial tissue.
Cytology, embryology,
General histology
Слайд 2Definition
Tissues -- groups of cells organised to perform one or more
functions.
Слайд 3Please, note and write down:
4 basic types of tissues:
Epithelial (Epithelium)
Connective
Muscular
Nervous
Слайд 4Please, note and write down:
There are two main types of Epithelial
Tissue:
1. Covering and lining
2. Glandular
Слайд 5Please, note and write down:
Covering and lining epithelia lie on the
free surface:
- cover outer body surfaces (i.e. skin) and
- line inner body surfaces:
-- lumen of hollow organs (i.e. intestine)
-- cavities (i.e. peritoneal cavity),
-- blood vessels,
-- ducts (in glands),
-- tubules (in kidneys).
Слайд 6Characteristics
Consists of cells only (there is no matrix).
Cells tightly appose
in sheets.
Cells rest on the basement membrane.
Note: connective tissue lie under the basement membrane
Слайд 7Importance :
Epithelium create a selective barrier between the organism and its
external environment:
any substances must pass through the epithelial cell, not between them.
Слайд 8Please, note and write down:
Two types of surface epithelia:
epithelium is simple,
when it is one cell layer thick
and stratified when it is two or more cell layer.
Слайд 9Maine functions
protection
diffusion or absorption or excretion = exchange
Слайд 10Another functions
transport (along free surface)
secretion
sensation.
Слайд 11Characteristics.
3. polarity - cells have 2 surfaces :
the apical or
free surface - towards the lumen or outside world
the basal surface, closest to the basement membrane
4. Epithelia are avascular, do not contain blood vessels, but are nourished by diffusion of substances from capillaries in underlying connective tissue.
5. It is frequently mitotically active
Слайд 12Shape of cells:
Squamous.
Cuboidal.
Columnar.
Слайд 13
!!! In case of stratified epithelia the second name describes
the shape of the top layer of cells.
Слайд 14Please, note and write down:
The morphology of the epithelium
correlates with
its function:
- Epithelia involved in secretion or absorption are typically simple.
-- Stratified epithelia usually impermeable and protective
Слайд 15 Simple Squamous Epithelium
lines blood vessels (endothelium), closed body cavities
(mesothelium), alveoli in the lungs
Function: controls diffusion, osmosis and filtration
Слайд 16Simple Cuboidal Epithelium
lines tubules and ducts
Слайд 17Simple Columnar
Lines stomach, intestine.
Usuallly has microvilli = finger-like projections of
cell membrane
Function – absorption.
Слайд 18 Pseudostratified
Single cell layer
All cells attach to basement membrane but
not all reach free surface
Nuclei at varying depths
Слайд 19Stratified squamous Epithelium
Several cell layers thick,
Surface cells flat
2 types:
Keratinized =
surface cells dead and filled with keratin
Example - Skin
Nonkeratinized = no keratin in moist, living cells at apical surface
Example - Cornea
Слайд 20Stratified Cuboidal Epithelium
Surface cells cuboidal
Lie in sweat gland ducts, male urethra
Слайд 21Stratified Columnar Epithelium
Surface cells columnar
Line very large ducts of gland, male
urethra
Слайд 22Multilayered
Surface cells varying in shape from round to flat if
stretched
Lines hollow organs of the urinary tract that expand from within
Transitional Epithelium
Слайд 23Please, note and write down:
!! The morphology of an epithelium often
correlates with its function:
- Epithelia involved in secretion or absorption are typically simple.
The height of the cell often reflects the level of secretory or absorptive activity.
-- Stratification of the epithelium usually correlates with impermeability and protection
Слайд 24GLANDULAR EPITHELIA
- form glands.
Function – secretion = synthesis and releasing
of substances.
Слайд 25GLANDULAR EPITHELIA
- Secretion – cyclic process.
4 phases:
1. diffusion of metabolites
into the cell
2. synthesis proper
3. releasing of substances from the cell
4. cell restoration
Слайд 26There are two types of gland in the body: exocrine and
endocrine.
Exocrine glands secrete through ducts or directly onto an surface (skin or cavity of inner organs).
Endocrine secrete hormones into the bloodstream.
Слайд 27By cell number
Unicellular
Ex.: Goblet cell
secrete mucus and lubricate small
and large intestine, respiratory tract
Multicellular
Слайд 282 portions of gland: Parenchyma and Stroma
Parenchyma - the epithelial,
secreting cells of the gland which perform the gland's essential function.
Stroma - supporting cellular framework of connective tissue which contains blood vessels and nerves and gives structure to the gland.
Слайд 29Two type of secretion
of Exocrine Glands
Mucous - viscous, slimy
(mucus
lines and lubricates cavities of all inner hollow organs)
Serous - watery
Ex.: exocrine pancreas (enzymes), sweet gland,
Fluid in serous cavities, joints.
Слайд 31Classification of Exocrine Glands by type of secretion
3. Mixed (Seromucous)
Ex.:
Submandibular and sublingual salivary glands; trachea and bronchi.
Слайд 323 types of secretion mechanism:
Merocrine (= eccrine)
Apocrine
Holocrine
Слайд 33Merocrine (most common):
Secretory granules fuse with the apical plasma membrane
and are secreted into the lumen of the gland.
Слайд 34Apocrine
(ex.: lactating mammary gland (fat droplet))
small portion of apical cytoplasm with
secretory granules is pinched off
Слайд 35Holocrine - ex: Sebaceous glands of skin
the cell fills with its
secretory product (lipids),
dies and disintegrates, releasing its product.
Слайд 37Mechanisms of Glandular Secretion
Слайд 38
A Structural Classification of Exocrine Glands
Слайд 39A Structural Classification of Exocrine Glands
By branching of duct exocrine glands
may be: simple (b-) or compound (b+)
By shape of secretory ends – tubular or alveolar (acinar)
By branching of secretory ends exocrine glands may be: branched (b+) or non-branched (b-)