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Corynebacterium Erysipelothrix & Listeria презентация
Содержание
- 3. Pathogenic Anaerobic Gram-Positive Bacilli
- 4. Corynebacteria (Genus Corynebacterium) ⮚Aerobic or facultatively anaerobic
- 5. Distinguishing Features of CMN Group
- 6. Pathogenic Corynebacterial Species Corynebacterium diphtheriae Corynebacterium jeikeium Corynebacterium urealyticum
- 7. Corynebacterium urealyticum ⮚Urinary tract infections (UTI’s);
- 8. Corynebacterium jeikeium ⮚Opportunistic infections in immunocompromised
- 9. Corynebacterium jeikeium Carriers
- 10. Corynebacterium diphtheriae ⮚Respiratory diphtheria (pseudomembrane on
- 11. Epidemiology of Diphtheria
- 12. Incidence of Diphtheria in the USA
- 13. Incidence of Diphtheria in Former Soviet Union
- 14. Virulence Factors in Corynebacterium Species
- 15. Diphtheria tox Gene in Beta Bacteriophage and Prophage
- 16. See Handout on Exotoxins
- 18. Mechanism of Action of Diphtheria Toxin:
- 19. Molecular Structure of Diphtheria Toxin
- 21. Diagnostic Schick Skin Test
- 22. In vivo Detection of Diphtheria Exotoxin
- 24. Listeria monocytogenes ⮚Gram-positive beta-hemolytic bacillus ⮚Multiply at
- 25. Intestinal tract of mammals & birds (especially
- 26. Epidemiology of Listeriosis
- 27. Epidemiology of Listeria Infections
- 28. Neonates, elderly & immunocompromised Granulomatosis infantiseptica
- 29. Methods That Circumvent Phagocytic Killing See Chpt. 19
- 30. Intracellular Survival & Replication of Listeria
- 32. Erysipelothrix rhusopathiae Gram-positive non-motile bacillus; forms filaments
- 33. Epidemiology of Erysipelothrix Infection
- 35. REVIEW
- 36. Corynebacterium diphtheriae ⮚Respiratory diphtheria (pseudomembrane on
- 37. Diphtheria tox Gene in Beta Bacteriophage and Prophage REVIEW
- 38. See Handout on Exotoxins REVIEW
- 39. Mechanism of Action of Diphtheria Toxin:
- 40. Corynebacterium jeikeium ⮚Opportunistic infections in immunocompromised
- 41. Corynebacterium urealyticum ⮚Urinary tract infections (UTI’s);
- 42. Listeria monocytogenes ⮚Gram-positive beta-hemolytic bacillus ⮚Multiply at
- 43. Epidemiology of Listeria Infections REVIEW
- 44. Neonates, elderly & immunocompromised Granulomatosis infantiseptica
- 45. Intracellular Survival & Replication of Listeria REVIEW
- 46. Erysipelothrix rhusopathiae Gram-positive non-motile bacillus; forms filaments
Pathogenic Anaerobic Gram-Positive Bacilli
Слайд 4Corynebacteria (Genus Corynebacterium)
⮚Aerobic or facultatively anaerobic
⮚Small, pleomorphic (club-shaped), gram-positive bacilli that
appear in short chains (“V” or “Y” configurations) or in clumps resembling “Chinese letters”
⮚Cells contain metachromatic granules (visualize with methylene blue stain)
⮚Lipid-rich cell wall contains meso-diaminopimelic acid, arabino-galactan polymers, and short-chain mycolic acids
⮚Lysogenic bacteriophage encodes for potent exotoxin in virulent strains
⮚Cells contain metachromatic granules (visualize with methylene blue stain)
⮚Lipid-rich cell wall contains meso-diaminopimelic acid, arabino-galactan polymers, and short-chain mycolic acids
⮚Lysogenic bacteriophage encodes for potent exotoxin in virulent strains
Слайд 6Pathogenic Corynebacterial Species
Corynebacterium diphtheriae
Corynebacterium jeikeium
Corynebacterium urealyticum
Слайд 7Corynebacterium urealyticum
⮚Urinary tract infections (UTI’s); rare but important
⮚Urease hydrolyzes urea; release
of NH4+, increase in pH, alkaline urine, renal stones
Слайд 8Corynebacterium jeikeium
⮚Opportunistic infections in immunocompromised (e.g., patients with blood disorders, bone
marrow transplants, intravenous catheters)
⮚Multiple antibiotic resistance common (MDR)
⮚Carriage on skin of up to 40% of hospitalized patients (e.g., marrow t-plants)
⮚Multiple antibiotic resistance common (MDR)
⮚Carriage on skin of up to 40% of hospitalized patients (e.g., marrow t-plants)
Слайд 10Corynebacterium diphtheriae
⮚Respiratory diphtheria (pseudomembrane on pharynx) and cutaneous diphtheria
⮚Prototype A-B exotoxin
acts systemically
Toxoid in DPT and TD vaccines
⮚Diphtheria toxin encoded by tox gene introduced by lysogenic bacteriophage (prophage)
⮚Selective media: cysteine-tellurite; serum tellurite; Loeffler’s
⮚Gravis, intermedius, and mitis colonial morphology
Toxoid in DPT and TD vaccines
⮚Diphtheria toxin encoded by tox gene introduced by lysogenic bacteriophage (prophage)
⮚Selective media: cysteine-tellurite; serum tellurite; Loeffler’s
⮚Gravis, intermedius, and mitis colonial morphology
Слайд 24Listeria monocytogenes
⮚Gram-positive beta-hemolytic bacillus
⮚Multiply at refrigerator temperatures (4oC)
⮚Tumbling motility at room
temperature
CAMP Test positive (like Group B Streptococcus)
CAMP Test positive (like Group B Streptococcus)
Слайд 25Intestinal tract of mammals & birds (especially chickens)
Persists in soil
Soft cheeses
& unwashed raw vegetables
Raw or undercooked food of animal origin
Luncheon meats
Hot dogs
Large scale food recalls have become common
Raw or undercooked food of animal origin
Luncheon meats
Hot dogs
Large scale food recalls have become common
Where do we find Listeria?
Слайд 28Neonates, elderly & immunocompromised
Granulomatosis infantiseptica
Transmitted to fetus transplacentally
Early septicemic
form: 1-5 days post-partum
Delayed meningitic form: 10-20 days following birth
Intracellular pathogen
Cell-mediated and humoral immunity develop
Only cell-mediated immunity is protective
Delayed meningitic form: 10-20 days following birth
Intracellular pathogen
Cell-mediated and humoral immunity develop
Only cell-mediated immunity is protective
Listeriosis
Слайд 32Erysipelothrix rhusopathiae
Gram-positive non-motile bacillus; forms filaments
Occupational disease of meat and fish
handlers, hunters, veterinarians
Preventable with protective gloves & clothing
Erysipeloid in humans; erysipelas in swine & turkeys
Organisms enter through break in skin
Nonsuppurative, self-limiting skin lesions with erythema and eruption
Peripheral spread may lead to generalized infection, septicemia and/or endocarditis
Organisms can be isolated from skin biopsy
Preventable with protective gloves & clothing
Erysipeloid in humans; erysipelas in swine & turkeys
Organisms enter through break in skin
Nonsuppurative, self-limiting skin lesions with erythema and eruption
Peripheral spread may lead to generalized infection, septicemia and/or endocarditis
Organisms can be isolated from skin biopsy
Слайд 36Corynebacterium diphtheriae
⮚Respiratory diphtheria (pseudomembrane on pharynx) and cutaneous diphtheria
⮚Prototype A-B exotoxin
acts systemically
Toxoid in DPT and TD vaccines
⮚Diphtheria toxin encoded by tox gene introduced by lysogenic bacteriophage (prophage)
⮚Selective media: cysteine-tellurite; serum tellurite; Loeffler’s
⮚Gravis, intermedius, and mitis colonial morphology
Toxoid in DPT and TD vaccines
⮚Diphtheria toxin encoded by tox gene introduced by lysogenic bacteriophage (prophage)
⮚Selective media: cysteine-tellurite; serum tellurite; Loeffler’s
⮚Gravis, intermedius, and mitis colonial morphology
REVIEW
Слайд 40Corynebacterium jeikeium
⮚Opportunistic infections in immunocompromised (e.g., patients with blood disorders, bone
marrow transplants, intravenous catheters)
⮚Multiple antibiotic resistance common (MDR)
⮚Carriage on skin of up to 40% of hospitalized patients (e.g., marrow t-plants)
⮚Multiple antibiotic resistance common (MDR)
⮚Carriage on skin of up to 40% of hospitalized patients (e.g., marrow t-plants)
REVIEW
Слайд 41Corynebacterium urealyticum
⮚Urinary tract infections (UTI’s); rare but important
⮚Urease hydrolyzes urea; release
of NH4+, increase in pH, alkaline urine, renal stones
REVIEW
Слайд 42Listeria monocytogenes
⮚Gram-positive beta-hemolytic bacillus
⮚Multiply at refrigerator temperatures (4oC)
⮚Tumbling motility at room
temperature
CAMP Test positive (like Group B Streptococcus)
CAMP Test positive (like Group B Streptococcus)
REVIEW
Слайд 44Neonates, elderly & immunocompromised
Granulomatosis infantiseptica
Transmitted to fetus transplacentally
Early septicemic
form: 1-5 days post-partum
Delayed meningitic form: 10-20 days following birth
Intracellular pathogen
Cell-mediated and humoral immunity develop
Only cell-mediated immunity is protective
Delayed meningitic form: 10-20 days following birth
Intracellular pathogen
Cell-mediated and humoral immunity develop
Only cell-mediated immunity is protective
Listeriosis
REVIEW
Слайд 46Erysipelothrix rhusopathiae
Gram-positive non-motile bacillus; forms filaments
Occupational disease of meat and fish
handlers, hunters, veterinarians
Preventable with protective gloves & clothing
Erysipeloid in humans; erysipelas in swine & turkeys
Organisms enter through break in skin
Nonsuppurative, self-limiting skin lesions with erythema and eruption
Peripheral spread may lead to generalized infection, septicemia and/or endocarditis
Organisms can be isolated from skin biopsy
Preventable with protective gloves & clothing
Erysipeloid in humans; erysipelas in swine & turkeys
Organisms enter through break in skin
Nonsuppurative, self-limiting skin lesions with erythema and eruption
Peripheral spread may lead to generalized infection, septicemia and/or endocarditis
Organisms can be isolated from skin biopsy
REVIEW
