“Astana Medical University”
Department of Internal Diseases № 1
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Bitabarova Dayan. 343gr презентация
Содержание
- 1. Bitabarova Dayan. 343gr
- 2. Definition of IDA It is a common
- 3. CLASSIFICATION OF ANEMIA Posthemorrhagic Hemolytic
- 4. Role of Iron Carrier of
- 5. Transferrin -protein responsible for transporting iron in
- 6. IRON SOURCES Non-heme iron Heme iron
- 7. IRON LOSSES NORMALLY Very small amounts
- 8. IDA
- 9. PATHOGENESIS OF IDA Blood loss Occult
- 10. CLINICAL SIGNS OF IDA
- 11. SOME OTHER FEATURES Pagophagia - craving
- 12. DIAGNOSING (TESTS) Peripheral blood smear
- 13. Hypochromia Normal analyses Found microcytes PERIPHERAL BLOOD SMEAR
- 14. BONE MARROW CHANGES
- 15. LAB FINDINGS IN IDA
- 16. DIFFERENTIAL DIAGNOSING Thalassemia trait (low MCV,
- 17. TREATMENT Oral iron unless there is
- 18. MEDICATION’S CLASSIFICATION ! No less than 20-30 mg Fe(2+)- as minimal diurnal dose.
- 19. PROGNOSIS The course and prognosis of iron
- 20. BIBLIOGRAPHY “Internal Diseases” 2nd edition. A.I. Martynov.,N.A.
Definition of IDA It is a common type of anemia — a condition in which blood lacks adequate healthy red blood cells. It is due to insufficient iron.
Слайд 1
SIW
THEME:
“IRON DEFICIENCY ANEMIA”
Checked by: Baidurin S.A
Done by: Bitabarova D. 343gr.
Astana 2018y.
JSC
Слайд 2Definition of IDA
It is a common type of anemia — a
condition in which blood lacks adequate healthy red blood cells. It is due to insufficient iron.
Слайд 3CLASSIFICATION OF ANEMIA
Posthemorrhagic
Hemolytic
Dyserithropoietic
According to pathogenesis
Слайд 4 Role of Iron
Carrier of oxygen from lung to tissues
Transport
of electrons within cells
Co-factor of essential enzymatic reactions:
Neurotransmission
Synthesis of steroid hormones
Synthesis of bile salts
Detoxification processes in the liver
Co-factor of essential enzymatic reactions:
Neurotransmission
Synthesis of steroid hormones
Synthesis of bile salts
Detoxification processes in the liver
Слайд 5Transferrin -protein responsible for transporting iron in the body.
Tissues with higher
requirement for iron ( bone marrow, liver & placenta) contain more transferrin receptors.
! Hemosiderin – long term iron storage pool
IRON CYCLE
Ferritin – intracellular storage of iron
Слайд 7IRON LOSSES NORMALLY
Very small amounts in urine, bile and sweat
Cells
shed from skin, intestinal and urinary tracts
Menstrual blood loss
Pregnancy and lactation
Menstrual blood loss
Pregnancy and lactation
Слайд 8IDA
Iron
substance in red blood cells can’t carry oxygen to body tissue
Heme is containing
an Fe atom
! Then it leads to pathogenesis of IDA
Слайд 9PATHOGENESIS OF IDA
Blood loss
Occult or overt blood losses,
traumatic or
surgical losses,
hemorrhages
Failure to meet increased requirements
Rapid growth in infancy and adolescence
Menstruation
pregnancy
Inadequate iron absorption
Diet low in heme iron
Gastrointestinal disease or surgery
hemorrhages
Failure to meet increased requirements
Rapid growth in infancy and adolescence
Menstruation
pregnancy
Inadequate iron absorption
Diet low in heme iron
Gastrointestinal disease or surgery
Слайд 11SOME OTHER FEATURES
Pagophagia - craving ice
Pica - craving of nonfood
substances
e.g., dirt, clay, laundry starch
Restless Legs
angular stomatitis - cracking of corners of mouth
Koilonychia - thin, spoon-shaped fingernails
e.g., dirt, clay, laundry starch
Restless Legs
angular stomatitis - cracking of corners of mouth
Koilonychia - thin, spoon-shaped fingernails
Слайд 12DIAGNOSING (TESTS)
Peripheral blood smear
Red cell indices (MCV, MCH)
Serum ferritin
Serum iron /
transferrin = iron saturation
Bone marrow iron stain (Prussian blue)
Bone marrow iron stain (Prussian blue)
Слайд 16DIFFERENTIAL DIAGNOSING
Thalassemia trait (low MCV, normal RDW)
Imbalance of globin chain
production
Anemia of inflammation
Decreased iron utilization in the face of adequate iron stores
Low ferritin / serum transferrin receptor
Anemia of inflammation
Decreased iron utilization in the face of adequate iron stores
Low ferritin / serum transferrin receptor
Слайд 17TREATMENT
Oral iron unless there is an absorptive problem.
Dietary sources:
Milk
less than 0.5l/day
More meat with iron
More meat with iron
+ FeSo4 BID.
Слайд 19PROGNOSIS
The course and prognosis of iron deficiency anemia is favorable with
timely diagnosis and adequate therapy
elimination of the etiologic factor (for example, the source of bleeding)
normalization of iron absorption
regular secondary prevention of iron deficiency (eg, donors, women with polymenorrhea
Слайд 20BIBLIOGRAPHY
“Internal Diseases” 2nd edition. A.I. Martynov.,N.A. Mukhin.,B.C. Moiseev.
Umbreit J.N., Conrad M.E.,
Moore E.G. and Latour L.F. Iron Absorption and Cellular Transport: The Mobilferrin \ Paraferritin Paradigm.
Perkins Sherrie L. Normal blood and bone marrow values in humans. In Wintrobe’s Clinical Hematology.
Wharton B.A. Detection and Prevention. Review. British Journal of Haematology
Perkins Sherrie L. Normal blood and bone marrow values in humans. In Wintrobe’s Clinical Hematology.
Wharton B.A. Detection and Prevention. Review. British Journal of Haematology
