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Protein and amino acid metabolism презентация
Содержание
- 1. Protein and amino acid metabolism
- 2. Protein-rich products
- 3. Essential amino acids valine, leucine,
- 4. Proteases Serine proteases Cysteine proteases Aspartic proteases Metalloproteases Treonine proteases Glutamic proteases
- 5. Active site of tripsin Active site of chymotripsin
- 6. HCL secretion
- 7. Pepsinogen activation
- 8. The selectivity of pepsin
- 9. Trypsinogen activation
- 10. Activation of intestinal proteases
- 11. The selectivity of peptidases
- 12. Amino acid absorption
- 13. Transport Catalytic cycle of GGT
- 14. Conversion of amino acids under the action of intestinal microflora
- 15. Proteolysis in tissues
- 16. Avram Hershko, Aaron Ciechanover and Irwin Rose Nobel Prize in Chemistry, 2004
- 17. Reactions of amino group Reductive deamination Hydrolytic deamination Intramolecular deamination urocanic acid histidine
- 18. Oxidative deamination
- 19. Transamination
- 20. Evaluation of transaminase activity Alanine + α-ketoglutarate → → pyruvate + glutamate AST ALT
- 21. Transaminases in human tissues (U/g protein)
- 22. de Ritis ratio АSТ АLТ = Myocardial
- 23. Decarboxylation
- 24. thiamine pyrophosphate
- 25. Decarboxylation glutamic acid γ-aminobutyric acid
- 26. Oxidative deamination of biogenic amines R-CH2-NH2 + E-FAD +
- 27. Ammonia neutrralisation
- 28. Urea cycle. Reactions 1, 2
- 29. Urea cycle. Reaction 3 Argininosuccinate synthetase
- 30. Urea cycle. Reaction 4 Argininosuccinase
- 31. Urea cycle. Reaction 5 Rate-limiting!
- 33. Kwashiorkor
- 35. Hereditary disorders of Urea cycle
Protein-rich products
Слайд 3Essential amino acids
valine, leucine, isoleucine, lysine, methionine, threonine, tryptophan,
phenylalanine
Semiessential amino acids
arginine and histidine
Слайд 4Proteases
Serine proteases
Cysteine proteases
Aspartic proteases
Metalloproteases
Treonine proteases
Glutamic proteases
Слайд 17Reactions of amino group
Reductive deamination
Hydrolytic deamination
Intramolecular deamination
urocanic acid
histidine
Слайд 26Oxidative deamination of biogenic amines
R-CH2-NH2 + E-FAD + H2O →
R-CHO + NH3 +
E-FAD⋅H2
E-FAD⋅H2 + O2 → E-FADH2 + H2O2
E-FAD⋅H2 + O2 → E-FADH2 + H2O2
Слайд 28Urea cycle. Reactions 1, 2
NH3 + CO2 +2
ATP + H2O
→ H2N-CO-OPO3H2 + 2 ADP + H3PO4
→ H2N-CO-OPO3H2 + 2 ADP + H3PO4
Carbamoylphosphate
synthetase
Ornithine transcarbamoilase
Rate-limiting!
