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Carbohydrate metabolism презентация
Содержание
- 1. Carbohydrate metabolism
- 2. Gluconeogenesis and glycolysis
- 3. Gluconeogenesis
- 5. OAA transport
- 9. The overall equation: 2 pyruvate + 2
- 11. Insulin Stimulate glucose transport into cells Induses
- 12. Glycolysis and gluconeogenesis regulation
- 13. Bi-functional enzyme
- 14. Bi-functional enzyme I/G↑ I/G↓
- 16. Regulation of phosphofructokinase activity
- 17. Regulation of pyruvate kinase activity
- 18. Glycogen Metabolism Glycogen in the cell
- 19. Glycogen structure
- 20. Glycogenesis (glycogen synthesis)
- 22. Glycogen syntase
- 25. glycogen branching enzyme
- 26. Glycogen synthase inactive Glycogen synthase active Phosphatase
- 27. Degradation of glycogen Glycogen phosphorylase
- 29. Action of debranching enzyme
- 30. Glycogen metabolism regulation
- 31. Glycogenosis Gierke's disease, glycogenosis type I Hepatocytes with large vacuoles Intracellular glycogen
- 32. Glycogenosis type I Glucose-6-phosphatase deficiency
- 33. Pompe’s disease, glycogenosis type II α-1,4-glucosidase deficiency
- 34. Corey's disease, glycogenosis type III Amilo-(1-6)-glycosidase and (or) glycogen branching enzyme deficiency
- 35. Andersen's disease, glycogenosis type IV glycogen branching enzyme deficiency
- 36. McArdle's disease, glycogenosis type V Muscle phosphorylase deficiency
- 37. PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) Oxidative phase
- 40. Xylulose-5 phospate Epimerase Isomerase Ribose-5 phospate Ribulose-5 phospate Nucleotides Nucleic Acids Nonoxidative phase
- 41. Glycolysis
- 43. Glycolysis
- 45. The overall equation: 6 G-6-P + 12
- 47. Violation of pentose phosphate pathway
Gluconeogenesis
and glycolysis
Слайд 9The overall equation:
2 pyruvate + 2 NADH + H+ + 4
ATP + 2 GTP →
→ glucose + 2 NAD+ + 4 ADP + 2 GDP + 6 Pi
→ glucose + 2 NAD+ + 4 ADP + 2 GDP + 6 Pi
Слайд 11Insulin
Stimulate glucose transport into cells
Induses synthesis of glucokinase, phosphofructokinase, pyruvate kinase
Activates
protein phosphatase → pyruvate kinase
Слайд 26Glycogen synthase
inactive
Glycogen synthase
active
Phosphatase
Protein kinase
P
OH
Regulation of glycogen synthase activity
Слайд 31Glycogenosis
Gierke's disease, glycogenosis type I
Hepatocytes with large vacuoles
Intracellular
glycogen
Слайд 34Corey's disease, glycogenosis type III
Amilo-(1-6)-glycosidase and (or) glycogen branching enzyme deficiency
Слайд 40Xylulose-5 phospate
Epimerase
Isomerase
Ribose-5 phospate
Ribulose-5 phospate
Nucleotides
Nucleic Acids
Nonoxidative phase
