Slowdown in emerging markets
Pricing pressures
Portfolio optimization
Maintaining revenue growth and operating margins
Unsustainable R&D costs
Integration challenges
Investors are prepared to take a more aggressive stance. 
One significant managerial misstep opens the door to activism.
Business pressures increased the importance of getting the capital agenda right
                                
Source: EY, FactSet’s Shark Repellent and Capital IQ.
Number of activist campaigns nearly doubled between 2010 and 2013-14
Number of activist campaigns initiated across all industries
                                
A third of activist campaigns
are driven by 
operational or 
business portfolio concerns. 
  Market capitalization ($USb)
                                
Simply put, “good enough” operational performance is less relevant if shareholders believe more could be done. 
                                
Big pharma: growth expected to revive in 2016
Specialty pharma/generics: growth via M&A
Biotech: growth hard to maintain organically
Source: EY, Capital IQ and company filings. 
                                
Source: EY and Capital IQ
* Ex-Gilead biotech margins: 41% Q1 2015, 34% 2014 
Big pharma
Biotech*
Specialty pharma
(incl. generics)
2012	     2013	         2014	   Q1 2015 
                                
Source: EY and Capital IQ. 
Company financials were calculated through 31 December 2014. See ey.com/vitalsigns for full analysis.
31 biopharma companies in data set, including four that were targets of activism in 2013 or 2014
                                
The biopharmas that drive the greatest value and productivity from their R&D organizations are the ones that have the most options with respect to capital allocation.
▬ Paul Clancy, CFO, Biogen
                                
Source: “Global Outlook for Medicines Through 2018,” IMS Health and FDA’s Center for Drug Evaluation and Research.
Number of NME approvals (FDA)
Biopharma pipeline renaissance: analysts project ~ 25% increase in approvals
                                
2014
2013
2012
2011
2010
2009
2008
2007
Source: EY, Capital IQ and company financial data.
Big pharma
Biotech and specialty pharma
                                
Big pharma companies have as much as US$50billion in excess working capital (WC)
Big pharma’s 2014 WC performance stronger than in 2007, but …
… WC varies widely overall along the metrics we track (e.g., DSO, DIO, DPO and C2C)
Individual opportunities for improvement, especially by adopting practices of leading WC performers in other industries
                                
Financial data is not generally captured in ways that make it easy to assess the business implications of different kinds of carve-outs. 
                                
Source: EY, Datamonitor, Company Reports. 
2015 data thru 4 June 2015.
. 
    2010	        2011	  2012	     2013	        2014	 2015
Specialty pharma
2015 pipeline (2H)
                                
Emergent
  Growing rapidly;  
  profitable or likely to be  
  soon
  Concerns:
Expanding operations 
Meeting changing expectations of stakeholders
Growth
   Measurable profits, due 
   to marketed products
   Concerns:
Maintaining growth
Balancing R&D, SG&A and other expenses with long-term growth
Mature
                                
Business portfolio
 and M&A
2
3
4
                                
Operational performance
1
Use milestone and “gating” mechanisms to improve R&D investment decisions.
R&D
2
Are capital allocation decisions based on the right metrics? Do they enable optimal use of the balance sheet?
Capital structure
3
Perform virtual carve-outs to assess the value of potential divestment opportunities.
Business portfolio and M&A
4
Communicate relentlessly with investors about strategic objectives.
Communications strategy
5
                                
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