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α-Aminoacids, peptides, proteins презентация
Содержание
- 1. α-Aminoacids, peptides, proteins
- 2. α-Aminoacids. α-Aminoacids – class of organic compounds,
- 3. Preparation of α-aminocarboxylic acids. 2. Aminolysis α-halogencarboxylic acids 1. Isolation from native sources.
- 4. 3. Strecker method Preparation of α-aminocarboxylic acids.
- 5. Chemical properties of α-aminocarboxylic acids. Formation of intramolecular salts pH of aqueous solutions ≈ 7
- 6. Chemical properties of α-aminocarboxylic acids. Formation of salts.
- 7. 1. Alkylation 2. Acylation Chemical properties of α-aminocarboxylic acids. Properties of amino-group.
- 8. 3. Reaction with nitrous acid. Chemical properties of α-aminocarboxylic acids. Properties of amino-group.
- 9. 1.Formation of esters. 2. Formation of halogenanhydrides.
- 10. 3. Formation of amides. Chemical properties of α-aminocarboxylic acids. Properties of carboxylic groups.
- 11. 1. Intramolecular dehydration. 2. Reaction with ninhydrin. Chemical properties of α-aminocarboxylic acids. Specific properties.
- 12. 4. Transamination 5. Reaction with с 2,4-dinitrofluorobenzene
- 13. 6. Reaction with phenylisothiocyanate (Erdman reaction) 7.
- 14. 8. Formation of complex compound 9. Decarboxylation Chemical properties of α-aminocarboxylic acids. Specific properties.
- 15. 1. Protection by benzyloxycarbonyl chloride. Chemical properties of α-aminocarboxylic acids. Protection of amino-group in aminoacids.
- 16. Chemical properties of α-aminocarboxylic acids. Protection of amino-group in aminoacids. 1. Protection by di-tert-butyl dicarbonate.
- 17. Proteinogenic aliphatic α-amino acids.
- 18. Proteinogenic aliphatic α-amino acids.
- 19. Proteinogenic aliphatic α-amino acids.
- 20. Proteinogenic aromatic α-amino acids.
- 21. Proteinogenic heterocyclic α-amino acids.
- 22. Essential α-aminoacids.
- 23. Biologically active compounds – derivatives of α-aminoacids. histidine histamine tryptophan serotonin thyroxine tyrosine
- 24. Peptides. Peptides – polyamides formed by α-aminoacids.
- 25. Synthesis of peptides. Possible products of interaction
- 26. Synthesis of peptides.
- 27. Proteins. Proteins – macromolecular compounds, polypeptides with
- 28. Interactions in protein molecules
- 29. Thank You for Your attention!
α-Aminoacids. α-Aminoacids – class of organic compounds, which may be considered as derivatives of carboxylic acids, in which hydrogen atom in position 2 substituted by amino group. Almost all
Слайд 1Zaporizhia State Medical University
Department of organic and bioorganic chemistry
Lecture
α-Aminoacids, peptides, proteins
Слайд 2α-Aminoacids.
α-Aminoacids – class of organic compounds, which may be considered
as
derivatives of carboxylic acids, in which hydrogen atom in position
2 substituted by amino group.
2 substituted by amino group.
Almost all α-aminoacids, except glycine (2-aminopropanoic acid)
contain asymmetric carbon, it means that optical isomerism is typical
for mentioned class of compounds.
Слайд 3Preparation of α-aminocarboxylic acids.
2. Aminolysis α-halogencarboxylic acids
1. Isolation from native sources.
Слайд 5Chemical properties of α-aminocarboxylic acids.
Formation of intramolecular salts
pH of aqueous solutions
≈ 7
Слайд 71. Alkylation
2. Acylation
Chemical properties of α-aminocarboxylic acids.
Properties of amino-group.
Слайд 83. Reaction with nitrous acid.
Chemical properties of α-aminocarboxylic acids.
Properties of amino-group.
Слайд 91.Formation of esters.
2. Formation of halogenanhydrides.
Chemical properties of α-aminocarboxylic acids.
Properties of
carboxylic groups.
Слайд 103. Formation of amides.
Chemical properties of α-aminocarboxylic acids.
Properties of carboxylic groups.
Слайд 111. Intramolecular dehydration.
2. Reaction with ninhydrin.
Chemical properties of α-aminocarboxylic acids.
Specific properties.
Слайд 124. Transamination
5. Reaction with с 2,4-dinitrofluorobenzene (Sanger reactive)
Chemical properties of α-aminocarboxylic
acids.
Specific properties.
Specific properties.
Слайд 136. Reaction with phenylisothiocyanate (Erdman reaction)
7. Reaction with compounds which contains
carbonyl fragment
Chemical properties of α-aminocarboxylic acids.
Specific properties.
Слайд 148. Formation of complex compound
9. Decarboxylation
Chemical properties of α-aminocarboxylic acids.
Specific properties.
Слайд 151. Protection by benzyloxycarbonyl chloride.
Chemical properties of α-aminocarboxylic acids.
Protection of amino-group
in aminoacids.
Слайд 16Chemical properties of α-aminocarboxylic acids.
Protection of amino-group in aminoacids.
1. Protection by
di-tert-butyl dicarbonate.
Слайд 23Biologically active compounds – derivatives of α-aminoacids.
histidine
histamine
tryptophan
serotonin
thyroxine
tyrosine
Слайд 25Synthesis of peptides.
Possible products of interaction between two α-aminoacids.
Alanine
Glycine
Ala-Ala
Ala-Gly
Gly-Gly
Gly-Ala
Слайд 27Proteins.
Proteins – macromolecular compounds, polypeptides with molecular
weigh more than10000.
Primary structure
– caused by amino acids sequence.
Secondary structure - regularly repeating local structures stabilized
by hydrogen bonds.
Tertiary structure - the spatial relationship of the secondary
structures to one another.
Quaternary structure - the structure formed by several protein
molecules bonded by non-covalent bonds.
Secondary structure - regularly repeating local structures stabilized
by hydrogen bonds.
Tertiary structure - the spatial relationship of the secondary
structures to one another.
Quaternary structure - the structure formed by several protein
molecules bonded by non-covalent bonds.
