Bogolyubov Institute for Theoretical Physics of the NAS of Ukraine
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13th Greta Pifat Mrzljak International School of Biophysics
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The mechanism of DNA deactivation by hydrogen peroxide action презентация
Содержание
- 1. The mechanism of DNA deactivation by hydrogen peroxide action
- 3. Solov’yov A. V., Surdutovich E.,
- 4. Hydrogen peroxide molecule The roal of H2O2 molecules in the ion beam therapy?
- 5. DNA macromolecule structure H2O2 H2O Na+ PO4
- 6. Atom-atomic potential function method
- 7. Potential parameters Zhurkin V. B., Poltev V. I., Florentiev V. L., Mol. Biol. 14, 1116 (1980)
- 8. H2O2 molecule with DNA phosphate group
- 9. Two-component complexes Necessity of trial complexes consideration
- 10. Three-component complexes
- 11. Low-frequency DNA vibration spectrum D.V. Pyatnytskyi, O.O.
- 12. Conclusions Changes to the life cell
- 13. Thank you for your attention!
Solov’yov A. V., Surdutovich E., Scifoni E., Mishustin I., Greiner W., Phys. Review. E 79, 011909 (2009) Secondary electrons Free radicals Mechanisms of DNA deactivation Structural
Слайд 1The mechanism of DNA deactivation by hydrogen peroxide action
Oleksii O. Zdorevskyi,
Sergey N. Volkov
Bogolyubov Institute for Theoretical Physics of the NAS of Ukraine
Bogolyubov Institute for Theoretical Physics of the NAS of Ukraine
Слайд 3
Solov’yov A. V., Surdutovich E., Scifoni E., Mishustin I., Greiner W., Phys.
Review. E 79, 011909 (2009)
Secondary
electrons
Free radicals
Mechanisms of DNA deactivation
Structural changes of the medium?
Слайд 7Potential parameters
Zhurkin V. B., Poltev V. I., Florentiev V. L., Mol. Biol. 14, 1116
(1980)
Слайд 11Low-frequency DNA vibration spectrum
D.V. Pyatnytskyi, O.O. Zdorevskyi, S.M. Perepelytsya, S.N.Volkov, EPJ
D, 2015
Arrhenius lifetime equations
Слайд 12Conclusions
Changes to the life cell medium structure as a result
of ionizing radiation action is analyzed. Dominant role of hydrogen peroxide molecule in this process is determined.
Binding energies of complexes of DNA phosphate group with different molecules are estimated. It is determined that hydrogen peroxide in the presence of sodium counterion can form stable complex with DNA phosphate group.
Vibration frequencies and living times of these complexes are estimated. It is determined that complex H2O2-DNA is more long-living than the complex H2O-DNA.
It is determined that hydrogen peroxide molecules can form a stable long-living complex with DNA which blocks the process of protein-nucleic recognition and genetic information transition. This may be a key mechanism in the ion therapy treatment.
Binding energies of complexes of DNA phosphate group with different molecules are estimated. It is determined that hydrogen peroxide in the presence of sodium counterion can form stable complex with DNA phosphate group.
Vibration frequencies and living times of these complexes are estimated. It is determined that complex H2O2-DNA is more long-living than the complex H2O-DNA.
It is determined that hydrogen peroxide molecules can form a stable long-living complex with DNA which blocks the process of protein-nucleic recognition and genetic information transition. This may be a key mechanism in the ion therapy treatment.
