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Overview of immune system презентация
Содержание
- 1. Overview of immune system
- 2. The immune system consist of two interconnected
- 3. Innate immunity
- 4. Components of innate immunity
- 8. Pathogen recognition The receptors of the
- 9. Protein recognition receptors:
- 10. Protein recognition receptors: Toll-like receptors
- 12. Protein recognition receptors: C-type lectin receptors
- 14. Cytokine Cytokine are broad family of small
- 17. Cytokine/anticytokine therapy Therapies have been developed with
- 18. Adaptive immune system
- 19. Major players T and B lymphocytes
- 22. Humoral immunity B cells 1)Fab region 2)Fc
- 23. Origen of diversity – alternative splicing
- 25. Function of antibodies Prevent adhesion of pathogens
- 26. Adaptive immune system Cellular immunity
- 27. Cellular immunity
- 29. Origen of variation in TCR
- 30. How to know what happening in the cell?
- 31. MHC with peptide
- 32. Killer kiss
- 33. Cancer cells can inhibit T-cells
- 34. T-CAR
The immune system consist of two interconnected arms Innate immunity Detect molecular components shared with all pathogens Adaptive immunity Molecular components (“antigenes”) specific to individual pathogen
Слайд 2The immune system consist of two interconnected arms
Innate immunity
Detect molecular
components shared with all pathogens
Adaptive immunity
Molecular components (“antigenes”) specific to individual pathogen
Adaptive immunity
Molecular components (“antigenes”) specific to individual pathogen
Слайд 8Pathogen recognition
The receptors of the innate immune system recognize conserved
pathogen-associated molecular patterns (PAMPs).
Receptors are called pattern-recognition receptors (PRRs)
Receptors are called pattern-recognition receptors (PRRs)
Слайд 14Cytokine
Cytokine are broad family of small proteins
(5-20 kDa) that are
important in cell signaling.
Слайд 17Cytokine/anticytokine therapy
Therapies have been developed with the express aim to block/inhibitor
restore the activity of specific cytokines.
Слайд 22Humoral immunity
B cells
1)Fab region
2)Fc region
3)Heavy chain (blue) with one variable (VH)
domain followed by a constant domain (CH1), a hinge region, and two more constant (CH2 and CH3) domains
4)Light chain (green) with one variable (VL) and one constant (CL) domain
5)
Antigen binding site (paratope)
Hinge regions
4)Light chain (green) with one variable (VL) and one constant (CL) domain
5)
Antigen binding site (paratope)
Hinge regions
Слайд 25Function of antibodies
Prevent adhesion of pathogens (bacteria and viruses)
Neutralize toxins
Opsonization of
bacteria
Complement activation
Complement activation
