Overview of immune system презентация

The immune system consist of two interconnected arms Innate immunity Detect molecular components shared with all pathogens Adaptive immunity Molecular components (“antigenes”) specific to individual pathogen

Слайд 1Overview of immune system


Слайд 2The immune system consist of two interconnected arms
Innate immunity
Detect molecular

components shared with all pathogens
Adaptive immunity
Molecular components (“antigenes”) specific to individual pathogen


Слайд 3Innate immunity


Слайд 4Components of innate immunity


Слайд 8Pathogen recognition
The receptors of the innate immune system recognize conserved

pathogen-associated molecular patterns (PAMPs).
Receptors are called pattern-recognition receptors (PRRs)

Слайд 9Protein recognition receptors:


Слайд 10Protein recognition receptors: Toll-like receptors


Слайд 12Protein recognition receptors: C-type lectin receptors


Слайд 14Cytokine
Cytokine are broad family of small proteins
(5-20 kDa) that are

important in cell signaling.


Слайд 17Cytokine/anticytokine therapy
Therapies have been developed with the express aim to block/inhibitor

restore the activity of specific cytokines.

Слайд 18Adaptive immune system


Слайд 19Major players T and B lymphocytes


Слайд 22Humoral immunity B cells
1)Fab region
2)Fc region
3)Heavy chain (blue) with one variable (VH)

domain followed by a constant domain (CH1), a hinge region, and two more constant (CH2 and CH3) domains
4)Light chain (green) with one variable (VL) and one constant (CL) domain
5)
Antigen binding site (paratope)
Hinge regions

Слайд 23Origen of diversity – alternative splicing


Слайд 25Function of antibodies
Prevent adhesion of pathogens (bacteria and viruses)
Neutralize toxins
Opsonization of

bacteria
Complement activation

Слайд 26Adaptive immune system Cellular immunity


Слайд 27Cellular immunity


Слайд 29Origen of variation in TCR


Слайд 30How to know what happening in the cell?


Слайд 31MHC with peptide


Слайд 32Killer kiss


Слайд 33Cancer cells can inhibit T-cells


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